TissGDB: tissue-specific gene database in cancer

TissGDB is the tissue-specific gene annotation database in cancer, aiming to provide a resource or reference for cancer and the related disease studies in the context of tissue specificity.

In Brief

• The TissGDB WEBSITE is here.

• Publication Link Nucleic Acids Res. 2018 Jan 4;46(D1):D1031-D1038. doi: 10.1093/nar/gkx850

Representative Tissue-Specific Gene Expression Resources

• The Human Protein Atlas (HPA)
• Tissue-specific Gene Expression and Regulation (TiGER)
• Genotype-Tissue Expression (GTEx)

Develop Feature

• 2461 Tissue Specific Genes (TissGenes)
• Across 22 Tissue Types
• Match the 28 Cancer types of The Cancer Genome Atlas (TCGA)

Analyses

• Identified hundreds of TissGenes
• universally kept or lost tissue-specific gene expression
• cancer type-specific isoform expression
• fusion with oncogenes or tumor suppressor genes
• markers for protective or risk prognosis

Seven Categories of Annotations

1. TissGeneSummary
2. TissGeneExp
3. TissGene-miRNA
4. TissGeneMut
   • TissGeneSNV
   • TissGeneCNV
   • TissGeneFusions
5. TissGeneNet
   • CePIN
     • Cytoscape
     • R
6. TissGeneProg
   • overall survival, OS
   • relapse free survival, RFS
7. TissGeneClin
   • TissGeneDrug
   • TissGeneDisease